Presenter

Shervin Pejhan

Authors

Shervin Pejhan1, Ryan Wang2, Sachin Pandey3, Joseph Megyesi2, Claire Coire4, Lee Cyn Ang1,2

1 Department of Pathology & Lab Medicine, Western University, ON, Canada

2 Department of Clinical Neurological Sciences, Western University, ON, Canada

3 Department of Medical Imaging, Western University, ON, Canada

4 Department of Pathology, Trillium Health Partners, Mississauga Hospital, ON, Canada

Conflict of Interest

I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose.

Clinical Summary

A 76-year-old gentleman presented to the hospital with nausea, and vomiting, after his diabetes medication was switched from Empagliflozin to metformin. He had also a worsening gait instability for more than a year, and a coincidental headache during that admission that ended up in a CT-head which showed a mass in the 4th ventricle without obstructive hydrocephalus. His past medical history was curious for a low-grade prostatic adenocarcinoma (stage pT1a), diagnosed by TURP more than 4 years ago, left lower lung lobectomy of unknown reason in 2011, and a spinal tumor resected in 2002. The MRI showed a T2 weighted hyperintense mass centered in the 4th ventricle (2.9 x 2.9 x 2.5 cm). The lesion demonstrated heterogeneous enhancement, with apparent solid and cystic components. He underwent suboccipital craniectomy and resection of the 4th ventricular mass.

Discussion points

  1. What are the differential diagnoses for this lesion?

  2. What special stains, IHCs, or ancillary testing would be most informative?

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