Thursday, October 13 – 08:00 AM CDT
Jerzy Olszewsky Invited Lecture
Dr. Roland Auer, MD PhD
Dr. Auer’s Neuropathology training in London (see photo) was bookended by a previous MD from the University of Alberta and a subsequent PhD in brain damage from the University of Lund, Sweden. From 1985-2010 he ran a brain damage research laboratory focusing on hypoglycemia, ischemia, epilepsy, trauma and neurotoxicology. In 2013, he received his first case of alleged child abuse and for almost a decade has been returning to anatomical pathology roots in elucidating cause of death. In squash tournaments over the years, Dr. Auer has dropped in the category he has entered from B to C and now D, but he recently withdrew from a very minor sprain and he tells us he might break something if he plays tournaments now. He enjoys writing, most recently obituaries, beginning with that of Dr. John Kaufmann, then Stirling Carpenter and now John Plunkett. The three obituaries have artificially inflated Dr. Auer’s peer-reviewed publications to 132, cited over 12½ thousand times, obituaries included. Roland’s secret loves are physics and pathophysiology, not neuropathology, and he wants the audience to keep this a secret.
Title: Unexpected death in infants and toddlers
Throughout human history, infants and toddlers have died unexpectedly by simply stopping breathing. Their lungs reveal inflammatory thickening, comprising fatal flu pneumonia. 10 minutes of global ischemia leads to closure of cerebral microcirculation as a result of spreading depolarization, glymphatic inflow of CSF and influx around Virchow-Robin spaces.
Resuscitation and high blood pressure/flow around non-perfused brain leads to arterially sourced leakage across ischemic vessels in dura and retina, but not brain or uvea. Indoor living and vitamin D deficiency lead to pathological fractures in thorax and skull, the 2 regions undergoing the most rapid boney growth in infancy, without overlying bruising. To avoid misdiagnosis of polytrauma, autopsy protocols for infants and toddlers dying unexpectedly must include examination of the 5 lobes of the lungs for lymphocytes and histiocytes, bones, brain and pituitary, the latter always infarcted in non-perfused brain.
Learning Objectives:
- Determine cause of death in infant autopsy
- Examine lungs for inflammatory thickening
- Understand blood flow changes around non-perfused brain
- Know the bone diseases giving pathological fractures in infancy
COI Disclosure:
None to disclose.
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Presentation materials will be made available soon.
Friday, October 14 – 13:00 PM CDT
Invited Lecture
Brent Thoma, MD, MSc, FRCPC, MA, DRCPSC
Dr. Brent Thoma is a Professor at the University of Saskatchewan where he works as an emergency physician, trauma team leader, and medical education researcher. He is also a Clinician Educator involved with the implementation of Competence By Design at the Royal College of Physicians and Surgeons of Canada.
Title: The Rationale And Ramifications Of Cbd Approach To Medical Training
Underpinnings of competency based medical training
This presentation will describe the background, theory and evidence in support of Competency Based Medical Education
Learning Objectives:
- Discuss the rationale and ramifications of the implementation of Competence By Design in Neuropathology
COI Disclosure:
I have a relationship with a for-profit and/or a not-for-profit organization to disclose:
Royal College of Physicians and Surgeons of Canada, University of Saskatchewan College of Medicine, Harvard Medical School, New England Journal of Medicine, University of Cincinnati Children’s Hospital, Canadian Association of Emergency Physicians, University of British Columbia, and the Government of Ontario – : Payments for teaching, research, administration, and research.
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Friday, October 14 – 13:45 PM CDT
Invited Lecture
Dr. Marcio Gomes
Dr. Marcio Gomes is an Associate Professor of Pathology and Distinguished Teacher at the University of Ottawa. He obtained his medical degree in 1995, completed his residency training in 1999 and obtained his PhD in 2003, all at the University of Sao Paulo, Brazil. He moved to Sherbrooke, Quebec, in 2005, where he worked as an Assistant Professor until 2008. He has two main academic interests: thoracic pathology and medical education.
Dr. Gomes has developed many educational innovations and received several teaching and education awards, including the 2010 Award of Excellence and Innovation in Postgraduate Medical Education by the University of Ottawa, the 2014 Professional Association of Residents of Ontario (PARO) Clinical Teaching Award, and the Leadership in Education Award of the Canadian Association of Pathologists (CAP-ACP) in 2017. He completed his Masters in Health Professions Education at the University of Illinois at Chicago in 2020 supported by the RCPSC Robert Maudsley Fellowship for Studies in Medical Education.
Dr. Gomes is a clinician educator in the Specialties Unit of the Royal College of Physicians and Surgeons of Canada since 2017, where he works with the development of new Areas of Focused Competence and the implementation of Competency-byDesign. He is also the Regional Advisor for Latin America with Royal College International and participates in many international partnerships for the development of residency education. His main areas of interest in education are competency-based medical education, educational design, workplace-based instruction and assessment, continuing professional development, and interprofessional education.
TBC
Experiences with the introduction of competency based medical training in Anatomic Pathology
Description to come
Learning Objectives:
1. TBC
2. TBC
3. TBC
COI Disclosure:
TBC
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Title: Experiences with the introduction of competency based medical training in Anatomic Pathology
Through reflections on lived experiences and the theory behind competency-based medical education, I will invite participants to join an interactive discussion and find out: What is in there for me?
Learning Objectives:
- Consider the potential impact of the implementation of competency-based training
- Discuss how competency-based training can work on their benefit
COI Disclosure:
I have a relationship with a for-profit and/or a not-for-profit organization to disclose:
Roche, AstraZeneca, Eli Lilly – Honoraria
Bayer, AstraZeneca – Advisory board
Ontario Institute for Cancer Research – Research Grant
Abcellera Biologics Inc, Nkarta Inc, CRISPR Therapeutics AG – Shareholder
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Friday, October 14 – 14:30 PM CDT
Invited Lecture
Dr. Patrick Shannon, MD
Dr. Shannon is a graduate of McGill University and the University of Toronto. Upon completion of his medical degree, he trained in Toronto where he completed fellowships in Neuropathology and Anatomical Pathology.
Since 2005 he has worked at Mount Sinai Hospital, Toronto, as a Perinatal Pathologist and is currently the Medical Director of the autopsy and perinatal service there as well as an Associate Professor in LMP at the University of Toronto.
He is currently serving as Chair of the Specialty Committee for Neuropathology for the Royal College of Physicians and Surgeons and was the Residency Program Director for Neuropathology at the University of Toronto.
Title: CPD Implementation
Outline the rational for CBD structure and plans for the implementation of competency based medical training in Neuropathology
Learning Objectives:
- Describe the rationale for CBD structure
COI Disclosure:
None to disclose.
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Saturday, October 15 – 08:00 AM CDT
Gordon Mathieson Invited Lecture
Dr. G.R. Wayne Moore, BSc, MD, CM, FRCPC, FRCPath
Wayne Moore, BSc, MD, CM, FRCPC, FRCPath is Clinical Professor of Pathology and Laboratory Medicine (Neuropathology) at the University of British Columbia and is a Principal Investigator at the International Collaboration for Repair Discoveries (ICORD). He is Adjunct Professor in the Department of Neurology and Neurosurgery at McGill University and in the Division of BioMedical Sciences at Memorial University of Newfoundland. He received his BSc degree from Memorial University of Newfoundland and his MD, CM degree from McGill University. He did his Neurology residency at the Mayo Clinic and his Neuropathology residency at Queen’s University and is certified in both specialties.
His post-doctoral fellowship was in experimental neuropathology at Albert Einstein College of Medicine in New York, where he subsequently was on faculty in the Departments of Pathology and Neurology for several years before moving to Vancouver.
His current research interests are the neuropathology and pathogenesis of multiple sclerosis and their relationship to magnetic resonance imaging.
Title: Demyelination, multiple sclerosis, and MRI
The current fundamental principles of the neuropathology and pathogenesis of multiple sclerosis will be presented in terms of inflammatory demyelination, neurodegeneration and repair. The most obvious neuropathologic manifestation, white matter plaques, will be discussed as well as the more recently recognized grey matter plaques and the widespread non-plaque involvement in the disease. How these features relate to the clinical expression and imaging findings in the disease will also be discussed.
Learning Objectives:
- Understand current concepts of the neuropathology and pathogenesis of multiple sclerosis.
- Understand how these principles relate to the clinical and magnetic resonance imaging expression of multiple sclerosis.
COI Disclosure:
I have a relationship with a for-profit and/or a not-for-profit organization to disclose.
Multiple Sclerosis Society of Canada – Member of Medical Advisory Committee until Sept 2020
Multiple Sclerosis Society of Canada; International Collaboration on Repair Discoveries (ICORD) -Operating Research Grants; Seed Grants
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Saturday, October 15 – 08:50 AM CDT
David Robertson Invited Lecture
Dr. Michael Levin, MD
Dr. Michael Levin is the Saskatchewan MS Clinical Research Chair and Professor of Neurology and Anatomy, Physiology & Pharmacology at the University of Saskatchewan. He received his BS in Chemistry at George Washington University, his MD at Pennsylvania State University and neuroscience training at The Salk Institute. Dr. Levin completed his residency training in Neurology at the New York Hospital/Cornell Medical Center – Memorial Sloan Kettering Cancer Center where Drs. Fred Plum and Jerry Posner mentored him including while he was chief neurology resident. He then completed his MS post-doctoral fellowship at NIH.
He was recruited to the University of Tennessee where he moved up the ranks to professor with tenure, was Chief of the Neurology Service at the Memphis Veterans Affairs Medical Center and led the MS clinic and developed a translational research program based on the role that dysfunctional RNA binding proteins play in the pathogenesis of MS. His work has been published in The New England Journal of Medicine, Nature Medicine, Annals of Neurology, and Journal of Neuroscience Research. Dr. Levin has received more than 30 awards for academic excellence including a Canadian ‘Science, Technology, Innovation and Collaboration’ Award for the discovery of stress granules in the brains of MS patients and a Tri-agency New Frontiers Research Grant – one of the most competitive in Canada.
Dr. Levin is married to his lovely wife of more than 30 years, Dr. Audrey Zucker-Levin, and has two strappingly handsome sons and is an avid sailor and scuba diver.
Title: Multiple Sclerosis And Future Therapies
Dr. Levin will discuss how the neuropathology of MS shifted the worldwide focus of MS research. He will review the clinical features of MS and the neuropathology of neurodegeneration in MS. He will review current treatments for MS and show how current laboratory experiments will contribute to new treatments for MS.
Learning Objectives:
- Understand Clinical Features of MS
- Understand the Neuropathological Features of Neurodegeneration in MS
- Understand the pathophysiology of Neurodegeneration in MS
- Identify Treatments for MS
- Learn about novel approaches to treat MS based upon the Neuropathology of MS
COI Disclosure:
I have a relationship with a for-profit and/or a not-for-profit organization to disclose:
Merck Manual – Associate Editor, Neurology Section
Neuordiem, Biogen, Novartis, Roche – Speakers Bureaus, Neurology Article Authorship, Advisory Board
CIHR, Saskatchewan Health Research Foundation, University of Saskatchewan, Saskatoon City Hospital Foundation – Grants and Start-up Funds
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Saturday, October 15 – 10:00 AM CDT
Invited Lecture
Dr. E. Ann Yeh, MD
Dr. E. Ann Yeh is currently Professor of Paediatrics (Neurology) at the University of Toronto in Ontario, Canada, where she is the director of the MS and Neuroinflammatory Disorders Program at The Hospital for Sick Children (SickKids), and Senior Scientist in the Division of Neuroscience and Mental Health at the Hospital for Sick Children Research Institute. She is former Program Director of the Child Neurology Training Program at the University of Toronto, and currently heads the Fellowship training program in Neuroinflammatory Disorders at the Hospital for Sick Children. She leads multiple multisite, multi-investigator studies focused on lifestyle factors and visual and other outcomes in youth with neuroinflammatory disorders and has authored over 175 publications related to these subjects. She co-leads the Interventional Clinical Trials Infrastructure team at the Hospital for Sick Children. She is a member of the multiple editorial boards, including Neurology and Multiple Sclerosis Journal and is a Chief Editor of Multiple Sclerosis and Related Disorders.
Title: The Expanding Spectrum Of Pediatric Neuroinflammatory Disorders
Pediatric multiple sclerosis and immune mediated demyelination.
In this talk, Dr. Yeh will review the shifts in knowledge related to the epidemiology, clinical presentation and treatment of pediatric neuroinflammatory disorders, with specific attention to MS and related disorders.
Learning Objectives:
- Participants should be able to identify pediatric neuroinflammatory disorders.
COI Disclosure:
I have a relationship with a for-profit and/or a not-for-profit organization to disclose:
Biogen – Investigator initiated research.
Hoffman-Laroche, Horizon – Scientific Advisory Board.
Stem Cell Network, Ontario Institute of Regenerative Medicine, CIHR, MSSC, NMSS, CMSC, SickKids Foundation – Funding received.
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Saturday, October 15 – 10:50 PM CDT
Invited Lecture
Dr. Tanja Kuhlmann, MD PhD
Dr. Tanja Kuhlmann studied medicine at the University of Göttingen, Germany where she received her medical degree in 1998.She specialized in neuropathology and worked as medical resident and research fellow in different neuropathological departments in Germany and at McGill, Canada in the research groups of Dr. Jack Antel and Dr. Alan Peterson. In 2008, she became senior consultant and associate professor, Institute of Neuropatholohgy at the University Hospital Münster, Germany and in 2020 part-time adjunct professor, Department of Neurology and Neurosurgery, McGill University. Her key research interests are mechanisms leading to axonal and oligodendroglial pathology in demyelinating diseases. In recent years, she focused her research on iPSC technology and the derivation of human CNS cells from iPSC to study disease mechanisms. She has published several publications in well-known international journals on the topic of MS pathology, especially on oligodendroglial loss and remyelination as well as studies using iPSC-derived oligodendrocytes and neurons to understand disease mechanisms in demyelinating and neurodegenerative diseases.
Title: Neuropathology of MS and stem cells
Multiple sclerosis (MS) is the most frequent demyelinating disease in the central nervous system. MS disease courses present avariable combination of relapse driven disease activity and disease progression independent of relapses resulting in disabilityaccumulation. Although the relapse driven disease activity is highly amenable to therapeutic interventions, disease progression still cannot be prevented. Remyelination, the formation of new myelin sheaths after a demyelinating event, is an endogenous repair process and promotion of remyelination represents a promising new treatment approach to stop disease progression. In my presentation I discuss how inflammation and aging impairs oligodendroglial functions and how stem cell trechnologies can be used to study the consequences of inflammation and aging on oligodendrocytes.
Learning Objectives:
- Describe how stem cells can be used to study myelin diseases.
COI Disclosure:
I have a relationship with a for-profit and/or a not-for-profit organization to disclose:
Biogen, Roche, Novartis – speaker honoraria
Novartis – Advisory Board, research grant
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Saturday, October 15 – 11:40 AM CDT
Invited Lecture
Pamela Kanellis
Pamela is Assistant Vice-President, Research and the research lead at the MS Society of Canada. Throughout her career, she has focused on the health and life sciences sector, working closely with researchers, innovators and crosssector stakeholders in academia, government and industry to accelerate research and innovation.
Pamela was formerly a Senior Director, Research & Global Academy at CIFAR working to cultivate interdisciplinary research networks to address questions of global importance. As the lead of the Global Academy at CIFAR, she rapidly grew the visibility and reach of a new program for early career researchers from all over the world to develop the next generation of research leaders. Prior to this role, Pamela was a Program Officer at Grand Challenges Canada where she pioneered and led the non-communicable disease portfolio focused on improving mental health in developing countries, working closely with global partners at the WHO, NIH and London School of Hygiene and Tropical Medicine.
Pamela started her career at a strategy health and life sciences consulting firm working in research and innovation with clients from academia, biopharmaceutical industry, government and not-for-profits in Canada and abroad. Pamela received a PhD in molecular genetics from the University of Toronto in the area of DNA repair and genome stability and an honours BSc. in biochemistry from McMaster University.
Title: Patient Engagement In MS Research
Outlook of patients and public on MS research and treatment in Canada
Overview of MS research and how patients are involved in the research process, the impact on the MS patient and other insights on research funding.
Learning Objectives:
- Identify and understand how patients can be engaged in research.
COI Disclosure:
None to disclose.
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Presentation to come